Heroin addiction linked to a “locally hyperactive but globally disconnected” brain state during creative tasks

A new study published in Translational Psychiatry provides evidence that chronic heroin addiction impairs the neural networks responsible for creative thinking. The findings indicate that the brains of individuals with opioid dependence struggle to coordinate the generation and evaluation of new ideas. This research suggests that the addicted brain attempts to compensate for these disconnected networks by overworking specific local regions, resulting in inefficient cognitive processing.

The opioid crisis continues to be a major global health challenge, with high rates of relapse and overdose. Recovery from addiction requires more than just physical detoxification. It demands cognitive flexibility to cope with life stressors, manage cravings, and solve interpersonal problems without returning to drug use. Divergent thinking is a mental ability that allows people to generate multiple solutions to open-ended problems. This type of thinking is a primary component of creativity and helps individuals adapt to changing environments.

Previous science has mapped the ways heroin damages basic brain functions like memory and impulse control. However, less is understood about how the drug affects higher-level thinking processes that are essential for long-term rehabilitation. A lack of understanding in this area limits the development of treatments that could help patients rebuild their lives. The current study aimed to fill this gap by mapping the brain activity associated with creative thought in people with a history of heroin use.

“There has long been a cultural myth that psychoactive substances can enhance creativity, but scientific evidence has mostly focused on short-term effects and yielded inconsistent results. Our study aimed to address this gap by examining how chronic opioid addiction affects higher-order creative cognition from a neurophysiological perspective. We wanted to move beyond cultural narratives and provide objective neural evidence for how addiction may impair creativity,” said study author Haijun Duan, a professor at Shaanxi Normal University.

The research team recruited a total of 73 participants for the experiment. This sample included 38 individuals diagnosed with chronic heroin use disorder and 35 healthy control subjects. The researchers ensured the two groups were matched in terms of age, gender, and education level to rule out other influences on the results. All participants in the addiction group were recruited from rehabilitation centers and were currently in a state of abstinence.

To measure creative potential, the scientists utilized a standard psychological assessment known as the Alternative Uses Test. Participants were presented with common everyday objects, such as a brick or a ruler. They were then asked to generate as many novel and original uses for these objects as possible within a set time limit. This task specifically targets divergent thinking by forcing the brain to break away from standard associations.

While the participants performed this cognitive challenge, the researchers recorded their electrical brain activity. They used a high-density electroencephalogram (EEG) system with 64 sensors placed on the scalp. This technology allowed the team to track brain signals with millisecond precision. The researchers looked specifically at the power of brain waves in different regions and how well these regions communicated with one another.

The behavioral results indicated a deficit in the group with heroin use disorder. These individuals produced ideas that were objectively less original compared to the healthy control group. Despite their lower performance scores, the participants with addiction issues rated their own ideas as highly creative. This suggests a disconnection between their actual cognitive performance and their self-evaluation capabilities.

The brain imaging data provided a biological explanation for these behavioral differences. The researchers used advanced computer modeling to trace the scalp signals back to their sources in the brain. They found that the addiction group exhibited significantly higher electrical activity in the parietal lobe. This area of the brain is involved in processing sensory information and managing attention.

Specifically, the addiction group showed increased power in the alpha and beta frequency bands in the precuneus and superior parietal lobule. In a healthy brain, alpha waves often help suppress irrelevant information. The excessive activity in these regions suggests that the brains of individuals with heroin addiction were working harder to filter out distractions. This hyperactivity appears to be a compensatory mechanism to make up for deficits elsewhere.

While local brain activity was abnormally high, the connections between different brain networks were strikingly weak. The study focused on the interaction between the default mode network and the frontoparietal control network. The default mode network is typically active during imagination and idea generation. The frontoparietal network is responsible for evaluating those ideas and keeping the mind focused on the goal.

In healthy individuals, these two networks rapidly exchange information to produce creative thoughts. The EEG data showed that this cross-network coupling was significantly reduced in the heroin group. The communication breakdown was particularly evident between the right superior frontal gyrus and the left precuneus. The strength of the connection between these two specific nodes was a strong predictor of how well a person performed on the creativity test.

“One of the most unexpected findings was that, despite showing clear deficits in divergent thinking, individuals with chronic heroin addiction exhibited increased local brain activity in certain regions, particularly within the parietal cortex,” Duan told PsyPost. “This suggests that while large-scale network coordination—especially between the default mode network and the frontoparietal control network—was disrupted, some local neural circuits became overactive as a compensatory mechanism.”

“In other words, the addicted brain may still attempt to generate multiple ideas, but it does so in a fragmented and inefficient manner—working harder, yet connecting less effectively. This ‘locally hyperactive but globally disconnected’ pattern provides a novel perspective on how chronic addiction reshapes the neural architecture underlying divergent thinking.”

The researchers employed machine learning algorithms to verify the importance of these neural connections. The computer model was able to classify participants with high or low divergent thinking ability based solely on their brain connectivity patterns. The connection between the frontal and parietal regions emerged as the most accurate biological marker for cognitive impairment. This finding supports the idea that creativity relies on global network integration rather than just local brain activity.

“Individuals with chronic heroin addiction show significantly poorer performance in divergent thinking tasks, finding it more difficult to generate novel ideas or approach problems from alternative perspectives,” Duan explained. “EEG results indicate that the functional connectivity between two key brain networks—the default mode network and the frontoparietal network—is markedly reduced in these individuals.”

“These networks are essential for flexible thinking and creative idea generation. When such neural coordination is disrupted, the fluidity of thought and creative potential become constrained, and the spark of inspiration dims. This suggests that creativity does not arise from mental chaos, but rather from the precise coordination of a healthy brain operating in order and dynamic balance.”

These cognitive deficits may have real-world consequences for recovery. Reduced divergent thinking can make it difficult for individuals to see alternatives to drug use when they face stress. If a person cannot generate novel solutions to daily problems, they are more likely to fall back on established habits. The inability to accurately judge one’s own performance may also hinder the acceptance of feedback during therapy.

There are some limitations to this study that should be considered. The research was observational and looked at participants at a single point in time. It cannot definitively prove that heroin use caused these brain changes, as pre-existing differences may have contributed to addiction vulnerability. It is also unknown whether these neural deficits are permanent or if they can heal over time.

“Our next steps involve longitudinal and multimodal neuroimaging studies to track cognitive recovery during abstinence and explore whether neuromodulation techniques (like tACS or neurofeedback) could help restore creative and flexible thinking in addiction rehabilitation,” Duan said.

The study, “The impact of chronic heroin addiction on creative cognition: an EEG study based on divergent thinking,” was authored by Wenjuan Fu, Yifan Wang, Wanyi Li, Yujia Meng, Jiaqi Dang, Kai Yuan, and Haijun Duan.