Peripheral Neuropathic Pain Market Size in the 7MM was ~USD 12,000 Million, which is expected to increase by 2034

The Peripheral Neuropathic Pain Market is poised for significant growth due to the increasing awareness of the condition, advancements in therapeutic interventions, and the rising global burden of peripheral neuropathies.

DelveInsight’s “Peripheral Neuropathic Pain Market Insights, Epidemiology and Market Forecast – 2034” report delivers an in-depth understanding of the Peripheral Neuropathic Pain, historical and forecasted epidemiology as well as the Peripheral Neuropathic Pain market trends in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom, and Japan.

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Key Takeaways from the Peripheral Neuropathic Pain Market Report

• In November 2024:- Vertex Pharmaceuticals-A Phase 3, Randomized, Double-blind, Placebo- and Active-Controlled Study of the Efficacy and Safety of Suzetrigine in Subjects With Pain Associated With Diabetic Peripheral Neuropathy. The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine (SUZ) in participants with pain associated with diabetic peripheral neuropathy (DPN).
• In November 2024:- Afasci Inc.- This is a randomized, double-blind, placebo-controlled, multicenter Phase II study of the efficacy, safety, tolerability, and PK of oral AFA-281 in 300 patients with painful lumbosacral radiculopathy (PLSR). Patients will be randomized in to the placebo group or doses of AFA-281, titrated over 2 weeks to reach planned daily doses for Weeks 3 and 4. Trials will be conducted simultaneously at 3 sites to meet enrollment targets. The primary efficacy endpoint is 24-hour average pain score based on the 0-10-point Numeric Pain Rating Scale (NPRS) and key secondary endpoint is Oswestry Disability Index (ODI), rates of adverse events, and PK, among others.
• In 2023, the United States recorded the highest incidence of PNP among the 7MM, with ~35,200,000 reported cases.
• The 7MM saw the highest number of severe cases in post-operative and post-traumatic PNP, while moderate cases predominated in PHN in terms of severity.
• Estimates indicate that in 2023, the EU4 and the UK collectively reported approximately 19.3 million cases, with Germany representing the largest share at around 35% of the total cases.
• In 2023, diabetic peripheral neuropathy (DPN) accounted for the highest number of cases in the US, comprising approximately 50% of the total cases.
• The leading Peripheral Neuropathic Pain Companies such as Helixmith, WEX Pharmaceuticals Inc., Lexicon Pharmaceuticals Inc., Bayer, AlzeCure Pharma, Grünenthal, Mallinckrodt Pharmaceuticals., Pfizer, Inc., Novartis AG, Teva Pharmaceutical Industries Ltd., and others
• Promising Peripheral Neuropathic Pain Therapies such as ENGENSIS/VM202 (donaperminogene seltoplasmid), Halneuron, LX9211, BAY2395840, ACD440 gel, and others

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Peripheral Neuropathic Pain Epidemiology Segmentation in the 7MM

• Total Cases of Peripheral Neuropathic Pain
• Type-specific Cases of Peripheral Neuropathic Pain
• Treated Cases of Peripheral Neuropathic Pain

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Marketed Peripheral Neuropathic Pain Drugs

• QUTENZA (capsaicin): Grünenthal and Averitas Pharma

QUTENZA (capsaicin) 8% topical system, a non-systemic, non-opioid pain relief delivered in the form of a patch, indicated for treating neuropathic pain associated with postherpetic neuralgia or associated with diabetic peripheral neuropathy (DPN) of the feet in adults. Capsaicin is an agonist for the transient receptor potential vanilloid 1 receptor (TRPV1), an ion channel-receptor complex expressed on nociceptive nerve fibers in the skin. QUTENZA is marketed and distributed by Averitas. Currently, it is being evaluated under a Phase III trial in post-surgical neuropathic pain. The trial is expected to be completed by October 2024, with an estimated enrollment of 408 participants.

• ZTLIDO (lidocaine): Scilex Pharmaceuticals

ZTLIDO is a topical lidocaine system (1.8%) approved for relieving pain associated with postherpetic neuralgia. ZTLIDO is designed as a lighter, thinner product with improved adhesion relative to LIDODERM (lidocaine patch 5%) while providing a bioequivalent delivery of lidocaine in an efficient drug delivery system. Lidocaine is a local amide anesthetic; it blocks sodium ion channels required for initiating and conducting neuronal impulses.

Emerging Peripheral neuropathic pain Drugs

• SEMDEXA (SP-102): Scilex Holding Company

SP-102 is a preservative-free, surfactant-free, and particulate-free, novel epidural steroid injection (ESI) formulation of 10 mg dexamethasone sodium phosphate in a viscous gel solution for subacute lumbosacral radicular pain (Sciatica). Its extended local effect provides durable pain relief and significant improvement in functioning from a single injection with rapid onset.

• Adezunap (AP707): Apurano Pharmaceuticals

Apurano Pharmaceuticals’ investigational drug AP707, featuring the THC-focused active ingredient adezunap, has received EMA approval for DISCOVER approval studies. Utilizing the patented PuranoTec manufacturing process, cannabis flower undergoes processing to create an aqueous nanodispersion of cannabinoids, primarily ?-9-THC. Administered as a sublingual mouth spray, this dispersion allows for rapid and efficient absorption through the oral mucosa, facilitated by a water-soluble shell termed the smart coating. These SmartLipids, encapsulating lipophilic cannabinoids, remain stable in aqueous environments and can directly enter the bloodstream due to their small particle size (

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Peripheral Neuropathic Pain Market Outlook

Peripheral Neuropathic Pain Companies, such as Scilex Holding Company, Grünenthal and Averitas Pharma, Eli Lilly and Company, Mitsubishi Tanabe Pharma Corporation, AstraZeneca, Asahi Kasei Pharma, Veloxis Pharmaceuticals, and others, are evaluating their lead candidates in different stages of clinical development, respectively. They aim to investigate their products for the treatment of Peripheral Neuropathic Pain.

Scope of the Peripheral Neuropathic Pain Market Report

• Study Period: 2020–2034
• Coverage: 7MM
• Peripheral Neuropathic Pain Companies: Helixmith, WEX Pharmaceuticals Inc., Lexicon Pharmaceuticals Inc., Bayer, AlzeCure Pharma, Grünenthal, Mallinckrodt Pharmaceuticals., Pfizer, Inc., Novartis AG, Teva Pharmaceutical Industries Ltd., and others
• Peripheral Neuropathic Pain Therapies: ENGENSIS/VM202 (donaperminogene seltoplasmid), Halneuron, LX9211, BAY2395840, ACD440 gel, and others
• Peripheral Neuropathic Pain Therapeutic Assessment: Peripheral Neuropathic Pain current marketed and Peripheral Neuropathic Pain emerging therapies

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Table of Content

1. Peripheral Neuropathic Pain Market Report Introduction

2. Executive Summary for Peripheral Neuropathic Pain

3. SWOT analysis of Peripheral Neuropathic Pain

4. Peripheral Neuropathic Pain Patient Share (%) Overview at a Glance

5. Peripheral Neuropathic Pain Market Overview at a Glance

6. Peripheral Neuropathic Pain Disease Background and Overview

7. Peripheral Neuropathic Pain Epidemiology and Patient Population

8. Country-Specific Patient Population of Peripheral Neuropathic Pain

9. Peripheral Neuropathic Pain Current Treatment and Medical Practices

10. Peripheral Neuropathic Pain Unmet Needs

11. Peripheral Neuropathic Pain Emerging Therapies

12. Peripheral Neuropathic Pain Market Outlook

13. Country-Wise Peripheral Neuropathic Pain Market Analysis (2020–2034)

14. Peripheral Neuropathic Pain Market Access and Reimbursement of Therapies

15. Peripheral Neuropathic Pain Market Drivers

16. Peripheral Neuropathic Pain Market Barriers

17. Peripheral Neuropathic Pain Appendix

18. Peripheral Neuropathic Pain Report Methodology

19. DelveInsight Capabilities

20. Disclaimer

21. About DelveInsight

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