DelveInsight’s, “Severe Hypertriglyceridemia Pipeline Insight 2024” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Severe Hypertriglyceridemia pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
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Key Takeaways from the Severe Hypertriglyceridemia Pipeline Report
August 2024:- Ionis Pharmaceuticals- An Open-Label Extension Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Patients With Severe Hypertriglyceridemia (SHTG). This is a multi-center, open-label study of up to 700 participants with SHTG who would be rolled over from studies ISIS 678354-CS5 (NCT05079919) or ISIS 678354-CS6 (NCT05552326). Day 1 of this study may be same as the Week 53 visit of either ISIS 678354-CS5 or ISIS 678354-CS6, as applicable. Participants will receive olezarsen during the 53-week treatment period. The study will include a 31-day qualification Period, a 53-week treatment period, and a 13-week post-treatment period.
DelveInsight’s Severe Hypertriglyceridemia pipeline report depicts a robust space with 10+ active players working to develop 10+ pipeline therapies for Severe Hypertriglyceridemia treatment.
The leading Severe Hypertriglyceridemia Companies such as Arrowhead Pharmaceuticals, Ionis Pharmaceuticals, Inc., 89bio, Inc., Regeneron Pharmaceuticals, Kowa Research Institute, Inc., Mochida Pharmaceutical, Acasti Pharma Inc., NorthSea Therapeutics, Matinas BioPharma, and others.
Promising Severe Hypertriglyceridemia Therapies such as Olezarsen, Plozasiran Injection, and others.
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Severe Hypertriglyceridemia Emerging Drugs Profile
ARO-APOC3: Arrowhead Pharmaceuticals
ARO-APOC3 is designed to reduce production of Apolipoprotein C-III (apoC-III), a component of triglyceride rich lipoproteins (TRLs) including VLDL and chylomicrons and is a key regulator of triglyceride metabolism. The company believes that knocking down the hepatic production of apoC-III may result in reduced VLDL synthesis and assembly, enhanced breakdown of TRLs, and better clearance of VLDL and chylomicron remnants. Currently, it is in Phase II stage of clinical trial evaluation to treat Severe Hypertriglyceridemia.
Olezarsen: Ionis Pharmaceuticals
Olezarsen, formerly known as IONIS-APOCIII-LRx and AKCEA-APOCIII-LRx, is a ligand-conjugated (LICA) investigational antisense medicine designed to inhibit the production of apoC-III in the liver. ApoC-III is a protein that regulates triglyceride metabolism in the blood by inhibiting lipoprotein lipase that breakdown triglycerides and by preventing clearance of triglyceride-rich lipoproteins. ApoC-III is an independent risk factor for both pancreatitis and cardiovascular disease.
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Severe Hypertriglyceridemia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration
Inhalation
Inhalation/Intravenous/Oral
Intranasal
Intravenous
Intravenous/ Subcutaneous
NA
Oral
Oral/intranasal/subcutaneous
Parenteral
Subcutaneous
Severe Hypertriglyceridemia Products have been categorized under various Molecule types such as
Antibody
Antisense oligonucleotides
Immunotherapy
Monoclonal antibody
Peptides
Protein
Recombinant protein
Small molecule
Stem Cell
Vaccine
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Scope of the Severe Hypertriglyceridemia Pipeline Report
Coverage- Global
Severe Hypertriglyceridemia companies- Arrowhead Pharmaceuticals, Ionis Pharmaceuticals, Inc., 89bio, Inc., Regeneron Pharmaceuticals, Kowa Research Institute, Inc., Mochida Pharmaceutical, Acasti Pharma Inc., NorthSea Therapeutics, Matinas BioPharma, and others.
Severe Hypertriglyceridemia Therapies such as Olezarsen, Plozasiran Injection, and others.
Severe Hypertriglyceridemia Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
Severe Hypertriglyceridemia Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
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Table of Content
Introduction
Executive Summary
Severe Hypertriglyceridemia: Overview
Pipeline Therapeutics
Therapeutic Assessment
Severe Hypertriglyceridemia – DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
Olezarsen: Ionis Pharmaceuticals
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
ARO-APOC3: Arrowhead Pharmaceuticals
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Drug name: Company name
Drug profiles in the detailed report…..
Preclinical and Discovery Stage Products
Drug name: Company name
Drug profiles in the detailed report…..
Inactive Products
Severe Hypertriglyceridemia Key Companies
Severe Hypertriglyceridemia Key Products
Severe Hypertriglyceridemia- Unmet Needs
Severe Hypertriglyceridemia- Market Drivers and Barriers
Severe Hypertriglyceridemia- Future Perspectives and Conclusion
Severe Hypertriglyceridemia Analyst Views
Severe Hypertriglyceridemia Key Companies
Appendix
About Us
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