Women’s libido drops significantly during a specific phase of the menstrual cycle

New research suggests that women experience a distinct decrease in sexual motivation during a specific phase of the menstrual cycle known as the implantation window. This reduction in desire may serve an evolutionary function by lowering the risk of infection during a time when the body’s immune system is naturally suppressed. The study was published in the journal Evolution and Human Behavior.

Scientists initiated this investigation to explore potential functional reasons for fluctuations in sexual desire across the menstrual cycle. Biology dictates that for a pregnancy to be established, a fertilized egg must successfully attach to the lining of the uterus.

This process requires the mother’s immune system to lower its defenses locally within the reproductive tract. This immunosuppression prevents the body from attacking the embryo as if it were a foreign invader.

This necessary biological adjustment creates a period of increased vulnerability. The suppression of immune cells makes the reproductive tract more susceptible to sexually transmitted infections.

Pathogens can enter the uterus more easily during this time. The physiological mechanisms that help sperm reach the egg, such as uterine contractions, can inadvertently transport bacteria or viruses into the upper reproductive tract.

The authors hypothesized that evolution might have shaped human psychology to mitigate this risk. If sexual activity poses a greater cost to health during this specific window, natural selection may have favored mechanisms that reduce the drive for sex.

A temporary dip in libido would theoretically limit exposure to pathogens when the body is least equipped to fight them. This theory builds on the concept of motivational priorities. It suggests that the brain balances the reproductive benefits of sex against potential survival costs.

“The conjunction of two patterns motivated the hypotheses tested in the paper. First, evidence that immune responses may vary across the menstrual cycle was intriguing and led me to read more about the specific effects that have been documented,” explained study author James R. Roney, a professor and acting chair of the Department of Psychological and Brain Sciences at the University of California, Santa Barbara.

“Suppression of immune responses in the endometrium during the implantation window could increase susceptibility to sexually transmitted infections at that time, and other evidence did in fact support such increased susceptibility.”

“Second, I had previously noticed visual patterns in my own data and those depicted in the figures of other studies in which measures of women’s sexual motivation appeared to be especially low during the mid-luteal cycle phase region that encompasses the human implantation window.”

“Putting the two patterns together suggested that reduced sexual motivation might be a response that evolved to mitigate infection risk at that time. That led us to formally statistically test whether measures of sexual motivation were lower during the implantation window than at other times in the cycle using data from three large, daily diary studies that had been completed in my lab.”

The combined dataset included over 2,500 daily observations from undergraduate women. The researchers restricted their analysis to participants who were not using hormonal contraceptives. They also excluded cycles where pregnancy occurred or where cycle regularity was compromised.

Participants in all three studies completed online surveys every morning. They reported on their experiences and behaviors from the previous day. The primary measure of interest was a self-reported rating of sexual desire. Participants rated how much they desired sexual contact on a scale ranging from one to seven. A second key measure asked participants simply whether they had masturbated that day.

The researchers needed to map these behavioral reports onto the participants’ menstrual cycles with high precision. In two of the studies, participants used daily urine tests to detect surges in luteinizing hormone. In the other study, participants provided saliva samples to measure hormone levels. These biological markers allowed the team to pinpoint the day of ovulation for each cycle.

The implantation window was defined as the period from five to nine days after ovulation. This timeframe corresponds to the mid-luteal phase when progesterone levels are typically at their peak. It is the specific window when the uterine lining is receptive to an embryo.

The researchers used multi-level regression models to analyze the relationship between this window and sexual motivation. This statistical method accounts for the fact that each participant provided multiple days of data.

The analysis revealed consistent patterns across the three independent samples. Women reported significantly lower levels of sexual desire during the implantation window compared to other phases of their cycle.

This decline was statistically significant even when the researchers compared the implantation window to other non-fertile days. This suggests the drop is a distinct phenomenon rather than just a return to baseline following ovulation.

The researchers also examined frequencies of masturbation. The results showed that the odds of a woman masturbating were approximately one-third lower during the implantation window compared to the rest of the cycle. This indicates that the reduction in sexual motivation manifests in behavioral changes as well as psychological feelings.

“Because many variables (aside from hormonal influences) may influence sexual desire, it is difficult to say how much the effects that we detected would be noticed as practically significant in daily life,” Roney told PsyPost. “We do know that, on average, women did consciously report less desire at this time, and so our arguments provide a possible explanation for why women may notice lower desire specifically in the second half of the menstrual cycle during the implantation window.”

Further analysis compared the implantation window specifically to the fertile window. As seen in previous research, sexual desire peaked near ovulation when conception is possible. The drop in desire during the implantation window was distinct from this peak. The data indicates a specific suppression of motivation during the mid-luteal phase.

The researchers also investigated desire directed toward romantic partners. Among the subset of women in relationships, desire for their specific partner tended to decline during the implantation window. Interest in new or extra-pair partners also showed a decrease. These findings align with the theory that the body downregulates sexual interest generally to avoid pathogen exposure.

The researcher addressed whether the drop in desire was simply due to menstruation. Sexual activity often decreases during menstrual bleeding. However, the analysis showed that the drop in desire during the implantation window was significant even when compared only to days without menstrual bleeding. The effect was specific to the timeframe of endometrial receptivity.

These findings support the idea that the menstrual cycle involves a trade-off between reproductive opportunity and immune protection.

“Fairly strong evidence had supported the idea that, on average, women’s sexual desire may be relatively higher near ovulation on days when it is possible to conceive,” Roney explained. “Our findings suggest that, conversely, there may be a region of the menstrual cycle in which women’s desire tends to be especially suppressed.

“This region corresponds to the time when an embryo would attach to the uterine lining if conception had occurred. Immune responses are reduced during that implantation window to avoid attacking the embryo, but that immunosuppression may increase risk of contracting sexually transmitted infections at that time. Thus, the reduced sexual desire at this time may have evolved to reduce the risk of contracting pathogenic infections through sex.”

The study, like all research, does have some limitations. The sample consisted entirely of university students. These participants were young and mostly not cohabiting with long-term partners. Sexual patterns might differ in older populations or among couples trying to conceive. “It would be ideal to test replication of these patterns in other samples of women,” Roney said.

Future research could attempt to link these behavioral shifts to physiological signals. Measuring specific immune proteins or hormones associated with the implantation process could strengthen the evidence.

“We would like to rigorously investigate the physiological signals that may cause the reduced sexual motivation that we observed during the implantation window,” Roney said.

The study, “Decreased sexual motivation during the human implantation window,” was authored by James R. Roney, Zachary L. Simmons, Mei Mei, Rachel L. Grillot, and Melissa Emery Thompson.